Tag: ecorv length
Statins act as transient type I interferon inhibitors to enable the antitumor activity of modified vaccinia Ankara viral vectors
Background: Modified vaccinia virus Ankara (MVA) are genetically engineered non-replicating viral vectors. Intratumoral administration of MVA induces a cyclic GMP-AMP synthase-mediated kind I interferon (IFN) response and the manufacturing of excessive ranges of the transgenes engineered into the viral genome equivalent to tumor antigens to assemble most cancers vaccines. Though kind I IFNs are important for…
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Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment
The tumor microenvironment (TME) is a complex amalgam of tumor cells, immune cells, endothelial cells and fibroblastic stromal cells (FSC). Cancer-associated fibroblasts are generally seen as tumor-promoting entity. However, it is conceivable that particular FSC populations within the TME contribute to immune-mediated tumor control. Here, we show that intratumoral treatment of mice with a recombinant…
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A panel of real-time PCR assays for the detection of Bourbon virus, Heartland virus, West Nile virus, and Trypanosoma cruzi in major disease-transmitting vectors
Vector-borne pathogens, akin to Bourbon virus (BRBV), Heartland virus (HRTV), West Nile virus (WNV), and Trypanosoma cruzi (TCZ) are an excellent menace to public well being and animal well being. We developed a panel of TaqMan real-time PCR assays for pathogen surveillance. PCR targets had been chosen based mostly on nucleic acid sequences deposited in GenBank. Primers…
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