Intramolecular recombination enables the formation of hepatitis B virus (HBV) cccDNA in mice after HBV genome transfer using recombinant AAV vectors

The mouse shouldn’t be a pure host of hepatitis B virus (HBV) an infection and – regardless of engraftment of hepatocytes with the HBV receptor – doesn’t help formation of HBV covalently closed round (ccc) DNA serving as a template for viral transcription and allowing persistent an infection. In a current examine, cccDNA formation in…

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