lcabie

Vector competence of human-biting ticks Ixodes scapularis, Amblyomma americanum and Dermacentor variabilis for Powassan virus

Background: Powassan virus (POWV; genus Flavivirus) is the only real North American member of the tick-borne encephalitis sero-complex and an growing public well being risk within the USA. Maintained in nature by Ixodes spp. ticks, POWV has additionally been remoted from species of different laborious tick genera, but it’s unclear if these species can function vectors. Dermacentor variabilis and Amblyomma americanum share geographic and ecologic overlap with Ixodes spp. ticks and POWV transmission foci, elevating the chance that POWV may develop into established in these tick species and resulting in vary enlargement and elevated human threat. Subsequently, we assessed the competency of Ixodes scapularis, D. variabilis and A. americanum for POWV lineage II (POWV II).
Strategies: Larvae from all three species had been co-infested on POWV-infected Balb/c mice. The engorged larvae had been allowed to molt to nymphs and screened for the presence of POWV II RNA by reverse transcription-qPCR. Eight contaminated nymphs from every species had been allowed to individually feed on a naïve mouse. Mice had been screened for the presence of POWV II RNA to find out an infection standing.
Outcomes: The outcomes demonstrated that larvae from all three tick species had been capable of effectively purchase POWV II by way of feeding on viremic mice, keep an infection by way of molting and successively transmit POWV to naïve mice on the nymphal stage at comparable charges throughout all three species.
Conclusions: Our findings reveal that non-Ixodes tick species can function competent vectors for POWV and spotlight the potential function of those species within the ecology and epidemiology of POWV. Future research analyzing the potential implications of those findings on POWV epidemiology and the adaptability of POWV in these new vectors are warranted.
Key phrases: Amblyomma americanum; Dermacentor variabilis; Ixodes scapularis; Powassan virus; Vector competence.
Recombinant viral vectors are an necessary platform for vaccine supply. Our current examine has demonstrated distinct innate immune profiles in responding to viral vectors of various households (e.g., adenovirus vs. poxvirus): whereas human Ad5 vector is minimally innate immune stimulatory, the poxviral vector ALVAC induces robust innate response and stimulates type-I IFN and inflammasome activation. Nevertheless, influence of the innate immune signaling on vaccine-induced adaptive immunity in viral vector vaccination is much less clear. Right here, we confirmed that Modified Vaccinia Ankara (MVA), one other poxviral vector, stimulated type-I IFN response in innate immune cells by way of cGAS-STING. Utilizing MVA-HIV vaccine as a mannequin, we discovered that type-I IFN signaling promoted the technology of humoral immunity in MVA-HIV vaccination in vivo.
Following vaccination, type-I IFN receptor knockout (IFNAR1-/-) mice produced considerably decrease ranges of complete and HIV gp120-specific antibodies in comparison with the wild-type (WT) mice. In keeping with the antibody response, type-I IFN signaling deficiency additionally led to decreased ranges of plasma cells and memory-like B cells in comparison with these in WT mice. Moreover, evaluation of vaccine-induced CD4 T cells confirmed that type-I IFN signaling additionally promoted the technology of vaccine-specific CD4 T-cell response and T follicular helper (Tfh) response in mice. Collectively, our information point out a task of type-I IFN signaling in selling humoral immunity in poxviral vector vaccination. The examine means that modulating type-I IFN and its related innate immune pathways will doubtless have an effect on vaccine efficacy.
IMPORTANCE Viral vectors, together with MVA, are an necessary antigen supply platform and have been generally utilized in vaccine improvement. Understanding the innate host-viral vector interactions and its influence on vaccine-induced immunity is important however understudied. Utilizing MVA-HIV vaccination of WT and IFNAR1-/- mice as a mannequin, our examine reviews that type-I IFN signaling promotes humoral immunity in MVA vaccination, together with vaccine-induced antibody, B-cell, and Tfh responses. Findings of the current examine present insights not just for primary understanding of host-viral vector interactions, but additionally for enhancing vaccine design by doubtlessly modulating type-I IFN and its related innate immune pathways in viral vector vaccination.

Transduction of rat and human adipose-tissue derived mesenchymal stromal cells by adeno-associated viral vector serotype DJ

 

Ex vivo, gene remedy is a robust strategy holding nice guarantees for the therapy of each genetic and bought illnesses. Adeno-associated virus (AAV) vectors are a protected and environment friendly supply system for modification of mesenchymal stem cells (MSC) that would maximize their therapeutic advantages. Evaluation of MSC viability and purposeful exercise after an infection with new AAV serotypes is critical, attributable to AAV tropism to particular cell sorts.
We contaminated human and rat adipose-tissue MSC with hybrid AAV-DJ serotype vectors carrying GFP and SCF genes. GFP expression from AAV-DJ was about 1.5-fold superior to that noticed with AAV-2 and lasted for at the very least 21 days as was evaluated by movement cytometry and fluorescence microscopy. AAV-DJ proves to be appropriate for the an infection of rat and human MSC with an identical effectivity.
Contaminated MSC had been nonetheless viable however confirmed a 25-30% growth-rate slowdown. Furthermore, we discovered a rise of SERPINB2 mRNA expression in human MSC whereas expression of different oxidative stress markers and extracellular matrix proteins was not affected. These outcomes counsel that there’s a differential mobile response in MSC contaminated with AAV viral vectors, which must be taken into consideration as it might probably have an effect on the anticipated final result for the therapeutic software.
lcabie
lcabie

Plasticity of the lettuce infectious yellows virus minor coat protein (CPm) in mediating the foregut retention and transmission of a chimeric CPm mutant by whitefly vectors

Transmission of the crinivirus, lettuce infectious yellows virus (LIYV), is set by a minor coat protein (CPm)-mediated virion retention mechanism situated within the foregut of its whitefly vector. To higher perceive the features of LIYV CPm, chimeric CPm mutants engineered with totally different lengths of the LIYV CPm amino acid sequence and that of the crinivirus, lettuce chlorosis virus (LCV), had been constructed primarily based on bioinformatics and sequence alignment information. The 485 amino acid-long chimeric CPm of LIYV mutant, CPmP-1, incorporates 60 % (from place Three to 294) of LCV CPm amino acids.
The chimeric CPm of mutants CPmP-2, CPmP-Three and CPmP-Four incorporates 46 (place Three to 208), 51 (place Three to 238) and 41 % (place 261 to 442) of LCV CPm amino acids, respectively. All 4 mutants moved systemically, expressed the chimeric CPm and shaped virus particles.
Nevertheless, following acquisition feeding of the virus preparations, solely CPmP-1 was retained within the foreguts of a major variety of vectors and transmitted. In immuno-gold labelling transmission electron microscopy (IGL-TEM) evaluation, CPmP-1 particles had been distinctly labelled by antibodies directed in opposition to the LCV however not LIYV CPm. In distinction, CPmP-Four particles weren’t labelled by antibodies directed in opposition to the LCV or LIYV CPm, whereas CPmP-2 and -Three particles had been weakly labelled by anti-LIYV CPm however not anti-LCV CPm antibodies.
The distinctive antibody recognition and binding sample of CPmP-1 was additionally displayed within the foreguts of whitefly vectors that consumed CPmP-1 virions. These outcomes are in step with the speculation that the chimeric CPm of CPmP-1 is included into purposeful virions, with the LCV CPm area being doubtlessly uncovered on the floor and accessible to anti-LCV CPm antibodies.

Anti-CD163

DB-045-RTU-15 15 ml
EUR 424.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-CD163

DB-045-RTU-7 7 ml
EUR 277.2
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-CD163

DB045RTU-15 15 ml
EUR 424.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-CD163

DB045RTU-7 7 ml
EUR 277.2
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Mouse Cluster Of Differentiation (CD163) ELISA Kit

DLR-CD163-Mu-48T 48T
EUR 609.6
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Cluster Of Differentiation (CD163) in samples from serum, plasma or other biological fluids.

Mouse Cluster Of Differentiation (CD163) ELISA Kit

DLR-CD163-Mu-96T 96T
EUR 793.2
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Cluster Of Differentiation (CD163) in samples from serum, plasma or other biological fluids.

Rat Cluster Of Differentiation (CD163) ELISA Kit

DLR-CD163-Ra-48T 48T
EUR 609.6
Description: A sandwich quantitative ELISA assay kit for detection of Rat Cluster Of Differentiation (CD163) in samples from serum, plasma, tissue homogenates or other biological fluids.

Rat Cluster Of Differentiation (CD163) ELISA Kit

DLR-CD163-Ra-96T 96T
EUR 793.2
Description: A sandwich quantitative ELISA assay kit for detection of Rat Cluster Of Differentiation (CD163) in samples from serum, plasma, tissue homogenates or other biological fluids.

Mouse Cluster Of Differentiation (CD163) ELISA Kit

RD-CD163-Mu-48Tests 48 Tests
EUR 613.2

Mouse Cluster Of Differentiation (CD163) ELISA Kit

RD-CD163-Mu-96Tests 96 Tests
EUR 850.8

Rat Cluster Of Differentiation (CD163) ELISA Kit

RD-CD163-Ra-48Tests 48 Tests
EUR 613.2

Rat Cluster Of Differentiation (CD163) ELISA Kit

RD-CD163-Ra-96Tests 96 Tests
EUR 850.8

Mouse Cluster Of Differentiation (CD163) ELISA Kit

RDR-CD163-Mu-48Tests 48 Tests
EUR 640.8

Mouse Cluster Of Differentiation (CD163) ELISA Kit

RDR-CD163-Mu-96Tests 96 Tests
EUR 890.4

Rat Cluster Of Differentiation (CD163) ELISA Kit

RDR-CD163-Ra-48Tests 48 Tests
EUR 640.8

Rat Cluster Of Differentiation (CD163) ELISA Kit

RDR-CD163-Ra-96Tests 96 Tests
EUR 890.4

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 418.8

Anti-CD163 Antibody

A00812-1 100ug/vial
EUR 400.8

Anti-CD163 Antibody

PA1874 100ug/vial
EUR 352.8

Anti-CD163 Antibody

PA1874-1 100ug/vial
EUR 400.8

Anti-CD163 antibody

STJ110681 100 µl
EUR 332.4
Description: The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Anti-CD163 Antibody

STJ500423 100 µg
EUR 571.2

Anti-CD163 Antibody

STJ500424 100 µg
EUR 571.2

Anti-CD163 antibody

STJ160082 1 mL C
EUR 1129.2

Anti-CD163 antibody

STJ16100302 100 µg
EUR 864

Anti-CD163 antibody

STJ16100324 1 mL
EUR 1174.8

Anti-CD163 antibody

STJ180301 0.1 ml
EUR 258

Anti-CD163 antibody

STJ190009 200 µl
EUR 236.4
Description: Unconjugated Mouse monoclonal to CD163 (AS1A1)

Anti-Hu CD163 Purified

11-645-C025 0.025 mg
EUR 118.8

Anti-Hu CD163 Purified

11-645-C100 0.1 mg
EUR 189.6

Anti-CD163/M130 Antibody

A00812 100ul
EUR 476.4
Description: Rabbit IgG polyclonal antibody for Scavenger receptor cysteine-rich type 1 protein M130 (CD163) detection.tested for IF, IHC, WB in Human, Mouse, Rat. Various direct flourescent conjugates are available for FCM upon request. Please contact us for details.

Anti-Hu CD163 APC

1A-645-T025 25 tests
EUR 168

Anti-Hu CD163 APC

1A-645-T100 100 tests
EUR 288

Anti-Hu CD163 PE

1P-645-T025 25 tests
EUR 168

Anti-Hu CD163 PE

1P-645-T100 100 tests
EUR 288

Anti-CD163/M130 antibody

PAab09771 100 ug
EUR 426

anti- CD163/M130 Antibody

FNab09771 100µg
EUR 658.5
Description: Antibody raised against CD163/M130 

Anti-CD163 Antibody BIOTIN

STJ500425 100 µg
EUR 703.2

Anti-CD163 Antibody FITC

STJ500426 100 µg
EUR 703.2

Anti-CD163 Antibody BIOTIN

STJ500427 100 µg
EUR 703.2

Anti-CD163 Antibody FITC

STJ500428 100 µg
EUR 703.2

human CD163 antigen,CD163 LISA kit

201-12-0247 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human CD163 antigen(CD163)ISA kit

GA-E0263HM-48T 48T
EUR 346.8

Human CD163 antigen(CD163)ISA kit

GA-E0263HM-96T 96T
EUR 559.2

Human CD163 antigen(CD163)ISA kit

QY-E05066 96T
EUR 433.2

Mouse Anti Human Cd163 Monoclonal Antibody

CABT-47162MH 25 µg
EUR 446.4

Mouse Anti Human Cd163 Monoclonal Antibody

CABT-47163MH 0.2 mg
EUR 1057.2

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 336

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 336

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 336

Anti-CD163 Rabbit Monoclonal Antibody

M00812 100ug/vial
EUR 476.4
Description: Rabbit Monoclonal CD163 Antibody. Validated in IP, WB and tested in Human.

Anti-Hu CD163 PE-Cy7

T7-645-T025 25 tests
EUR 184.8

Anti-Hu CD163 PE-Cy7

T7-645-T100 100 tests
EUR 321.6

Anti-Hu CD163 PerCP-Cy5.5

T9-645-T025 25 tests
EUR 235.2

Anti-Hu CD163 PerCP-Cy5.5

T9-645-T100 100 tests
EUR 422.4

Purified Anti-human CD163 Antibody *GHI/61*

11630000 100 ug
EUR 365

APC Anti-human CD163 Antibody *GHI/61*

116301B0 25 tests
EUR 383

APC Anti-human CD163 Antibody *GHI/61*

116301B1 100 tests
EUR 995

APC Anti-human CD163 Antibody *GHI/61*

116301B2 500 tests
EUR 2984

FITC Anti-human CD163 Antibody *GHI/61*

116301G0 100 tests
EUR 547

FITC Anti-human CD163 Antibody *GHI/61*

116301G1 500 tests
EUR 2051

TRITC Anti-human CD163 Antibody *GHI/61*

116301H0 100 tests
EUR 547

TRITC Anti-human CD163 Antibody *GHI/61*

116301H1 500 tests
EUR 2051

PacBlue Anti-human CD163 Antibody *GHI/61*

116301I0 100 tests
EUR 547

PacBlue Anti-human CD163 Antibody *GHI/61*

116301I1 500 tests
EUR 2051

PacOrange Anti-human CD163 Antibody *GHI/61*

116301J0 100 tests
EUR 547

PacOrange Anti-human CD163 Antibody *GHI/61*

116301J1 500 tests
EUR 2051

PE Anti-human CD163 Antibody *GHI/61*

116301K0 25 tests
EUR 383

PE Anti-human CD163 Antibody *GHI/61*

116301K1 100 tests
EUR 995

PE Anti-human CD163 Antibody *GHI/61*

116301K2 500 tests
EUR 2984

PerCP Anti-human CD163 Antibody *GHI/61*

116301S0 25 tests
EUR 383

PerCP Anti-human CD163 Antibody *GHI/61*

116301S1 100 tests
EUR 995

PerCP Anti-human CD163 Antibody *GHI/61*

116301S2 500 tests
EUR 2984

Porcine CD163 antigen,CD163 LISA kit

GA-E0045PC-48T 48T
EUR 436.8

Porcine CD163 antigen,CD163 LISA kit

GA-E0045PC-96T 96T
EUR 708

Canine CD163 antigen(CD163 LISA kit

GA-E0062CN-48T 48T
EUR 482.4

Canine CD163 antigen(CD163 LISA kit

GA-E0062CN-96T 96T
EUR 820.8

CD163 Antibody

49553-100ul 100ul
EUR 399.6

CD163 Antibody

49553-50ul 50ul
EUR 286.8

CD163 Antibody

37157-100ul 100ul
EUR 302.4

CD163 antibody

10R-6496 100 ug
EUR 243.6
Description: Mouse monoclonal CD163 antibody

CD163 antibody

10R-CD163aRT 250 ug
EUR 859.2
Description: Mouse monoclonal CD163 antibody

CD163 Antibody

ABD8235 100 ug
EUR 525.6

CD163 Antibody

20-abx242956
  • EUR 560.40
  • EUR 393.60
  • 100 ul
  • 50 ul

CD163 siRNA

20-abx910930
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

CD163 siRNA

20-abx910931
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

CD163 Antibody

1-CSB-PA801238LA01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against CD163. Recognizes CD163 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IF; Recommended dilution: IF:1:50-1:200

Cd163 Antibody

1-CSB-PA650452LA01MO
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Cd163. Recognizes Cd163 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:500-1:2000

CD163 Antibody

1-CSB-PA969205
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against CD163. Recognizes CD163 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:25-1:100

CD163 Antibody

DF8235 200ul
EUR 420

CD163 Antibody

R30973 100 ug
EUR 419

CD163 Antibody

R30974 100 ug
EUR 419

CD163 Antibody

RQ4259 100 ug
EUR 419

CD163 Antibody

F50316-0.08ML 0.08 ml
EUR 165

CD163 Antibody

F50316-0.4ML 0.4 ml
EUR 379

CD163 Antibody

V3937-100UG 100 ug
EUR 499
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody

V3937-20UG 20 ug
EUR 219
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody

V3937SAF-100UG 100 ug
EUR 499
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody

V7470-100UG 100 ug
EUR 499
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody

V7470-20UG 20 ug
EUR 219
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody

V7470IHC-7ML 7 ml
EUR 499
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody

V7470SAF-100UG 100 ug
EUR 499
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody

V8227-100UG 100 ug
EUR 499
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody

V8227-20UG 20 ug
EUR 219
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody

V8227SAF-100UG 100 ug
EUR 499
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody

V8415-100UG 100 ug
EUR 499
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody

V8415-20UG 20 ug
EUR 219
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody

V8415SAF-100UG 100 ug
EUR 499
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody

V8757-100UG 100 ug
EUR 499
Description: CD163 is a type I membrane protein, and is a member of the hemoglobin scavenger receptor cystein-rich superfamily. The protein is involved in the clearance of hemoglobin-haptoglobin complexes and is considered to have anti-inflammatory functions. CD163 expression is restricted to the monocytic/macrophage lineage. It is expressed by all circulating monocytes and by a majority of tissue macrophages, such as splenic dendrocytes, alveolar macrophages and Kupffer cells of the liver. It is not present in macrophages in the mantle zone and some of the germinal center cells in lymph follicles, nor in Langerhans cells and interdigitating reticulum cells. In tumor tissues, CD163 is found in almost all cases of acute myeloid leukemia with monocytoid differentiation and in the majority of cases of histiocytic sarcoma, littoral cell angioma, Rosai-Dorfman disease, Langerhans cell histiocytosis and typical and atypical fibrous histiocytoma. It is also expressed in some cases of dermatofibrosarcoma protuberans. CD163 can be used to detect cells of monocytic and histiocyte lineage in neoplastic and reactive lesions. It has been shown to be more sensitive than CD68 for the detection of macrophages and monocytic cells. It covers a similar, but not identical, spectrum of cells as CD68.

CD163 Antibody

V8757-20UG 20 ug
EUR 219
Description: CD163 is a type I membrane protein, and is a member of the hemoglobin scavenger receptor cystein-rich superfamily. The protein is involved in the clearance of hemoglobin-haptoglobin complexes and is considered to have anti-inflammatory functions. CD163 expression is restricted to the monocytic/macrophage lineage. It is expressed by all circulating monocytes and by a majority of tissue macrophages, such as splenic dendrocytes, alveolar macrophages and Kupffer cells of the liver. It is not present in macrophages in the mantle zone and some of the germinal center cells in lymph follicles, nor in Langerhans cells and interdigitating reticulum cells. In tumor tissues, CD163 is found in almost all cases of acute myeloid leukemia with monocytoid differentiation and in the majority of cases of histiocytic sarcoma, littoral cell angioma, Rosai-Dorfman disease, Langerhans cell histiocytosis and typical and atypical fibrous histiocytoma. It is also expressed in some cases of dermatofibrosarcoma protuberans. CD163 can be used to detect cells of monocytic and histiocyte lineage in neoplastic and reactive lesions. It has been shown to be more sensitive than CD68 for the detection of macrophages and monocytic cells. It covers a similar, but not identical, spectrum of cells as CD68.

CD163 Antibody

V8757SAF-100UG 100 ug
EUR 499
Description: CD163 is a type I membrane protein, and is a member of the hemoglobin scavenger receptor cystein-rich superfamily. The protein is involved in the clearance of hemoglobin-haptoglobin complexes and is considered to have anti-inflammatory functions. CD163 expression is restricted to the monocytic/macrophage lineage. It is expressed by all circulating monocytes and by a majority of tissue macrophages, such as splenic dendrocytes, alveolar macrophages and Kupffer cells of the liver. It is not present in macrophages in the mantle zone and some of the germinal center cells in lymph follicles, nor in Langerhans cells and interdigitating reticulum cells. In tumor tissues, CD163 is found in almost all cases of acute myeloid leukemia with monocytoid differentiation and in the majority of cases of histiocytic sarcoma, littoral cell angioma, Rosai-Dorfman disease, Langerhans cell histiocytosis and typical and atypical fibrous histiocytoma. It is also expressed in some cases of dermatofibrosarcoma protuberans. CD163 can be used to detect cells of monocytic and histiocyte lineage in neoplastic and reactive lesions. It has been shown to be more sensitive than CD68 for the detection of macrophages and monocytic cells. It covers a similar, but not identical, spectrum of cells as CD68.

Human CD163 shRNA Plasmid

20-abx956176
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human CD163 ELISA Kit

LF-EK50890 1×96T
EUR 777.6

Human CD163 ELISA Kit

ELA-E1726h 96 Tests
EUR 988.8

Mouse Anti Rat Cd163 Monoclonal Antibody

DMABT-47170MR 0.25 mg
EUR 889.2

Mouse Anti Rat Cd163 Monoclonal Antibody

DMABT-47171MR 0.1 mg
EUR 670.8

Anti-Human CD163 DyLight® 488 conjugated Antibody

A00812-Dyl488 100ug/vial
EUR 412.8

Anti-Human CD163 DyLight® 550 conjugated Antibody

A00812-Dyl550 100ug/vial
EUR 412.8

Mouse Anti-Human CD163 monoclonal antibody, clone JID274

CABT-L2938-100uL500uL 100 uL, 500 uL
EUR 602.4

APC/Cy7 Anti-human CD163 Antibody *GHI/61*

116301C0 25 tests
EUR 429

APC/Cy7 Anti-human CD163 Antibody *GHI/61*

116301C1 100 tests
EUR 1117

APC/Cy7 Anti-human CD163 Antibody *GHI/61*

116301C2 500 tests
EUR 3351

PE/Cy5 Anti-human CD163 Antibody *GHI/61*

116301L0 25 tests
EUR 429

PE/Cy5 Anti-human CD163 Antibody *GHI/61*

116301L1 100 tests
EUR 1117

PE/Cy5 Anti-human CD163 Antibody *GHI/61*

116301L2 500 tests
EUR 3351

PE/Cy7 Anti-human CD163 Antibody *GHI/61*

116301M0 25 tests
EUR 429

PE/Cy7 Anti-human CD163 Antibody *GHI/61*

116301M1 100 tests
EUR 1117

PE/Cy7 Anti-human CD163 Antibody *GHI/61*

116301M2 500 tests
EUR 3351

PerCP/Cy5.5 Anti-human CD163 Antibody *GHI/61*

116301T0 25 tests
EUR 429

PerCP/Cy5.5 Anti-human CD163 Antibody *GHI/61*

116301T1 100 tests
EUR 1117

PerCP/Cy5.5 Anti-human CD163 Antibody *GHI/61*

116301T2 500 tests
EUR 3351

Human CellExp? CD163, Human recombinant

9226-10
EUR 366

Human CellExp? CD163, Human recombinant

9226-50
EUR 927.6

iFluor® 350 Anti-human CD163 Antibody *GHI/61*

11630010 100 tests
EUR 547

iFluor® 350 Anti-human CD163 Antibody *GHI/61*

11630011 500 tests
EUR 2051

iFluor® 405 Anti-human CD163 Antibody *GHI/61*

11630020 100 tests
EUR 547

iFluor® 405 Anti-human CD163 Antibody *GHI/61*

11630021 500 tests
EUR 2051

iFluor® 430 Anti-human CD163 Antibody *GHI/61*

11630030 100 tests
EUR 547

iFluor® 430 Anti-human CD163 Antibody *GHI/61*

11630031 500 tests
EUR 2051

iFluor® 450 Anti-human CD163 Antibody *GHI/61*

11630040 100 tests
EUR 547

iFluor® 450 Anti-human CD163 Antibody *GHI/61*

11630041 500 tests
EUR 2051

iFluor® 488 Anti-human CD163 Antibody *GHI/61*

11630050 100 tests
EUR 547

iFluor® 488 Anti-human CD163 Antibody *GHI/61*

11630051 500 tests
EUR 2051

iFluor® 514 Anti-human CD163 Antibody *GHI/61*

11630060 100 tests
EUR 547

iFluor® 514 Anti-human CD163 Antibody *GHI/61*

11630061 500 tests
EUR 2051

iFluor® 532 Anti-human CD163 Antibody *GHI/61*

11630070 100 tests
EUR 547

iFluor® 532 Anti-human CD163 Antibody *GHI/61*

11630071 500 tests
EUR 2051

iFluor® 546 Anti-human CD163 Antibody *GHI/61*

11630080 100 tests
EUR 547

iFluor® 546 Anti-human CD163 Antibody *GHI/61*

11630081 500 tests
EUR 2051

iFluor® 555 Anti-human CD163 Antibody *GHI/61*

11630090 100 tests
EUR 547

iFluor® 555 Anti-human CD163 Antibody *GHI/61*

11630091 500 tests
EUR 2051

iFluor® 560 Anti-human CD163 Antibody *GHI/61*

116300A0 100 tests
EUR 547

iFluor® 560 Anti-human CD163 Antibody *GHI/61*

116300A1 500 tests
EUR 2051

iFluor® 568 Anti-human CD163 Antibody *GHI/61*

116300B0 100 tests
EUR 547

iFluor® 568 Anti-human CD163 Antibody *GHI/61*

116300B1 500 tests
EUR 2051

iFluor® 594 Anti-human CD163 Antibody *GHI/61*

116300C0 100 tests
EUR 547

iFluor® 594 Anti-human CD163 Antibody *GHI/61*

116300C1 500 tests
EUR 2051

iFluor® 610 Anti-human CD163 Antibody *GHI/61*

116300D0 100 tests
EUR 547

iFluor® 610 Anti-human CD163 Antibody *GHI/61*

116300D1 500 tests
EUR 2051

iFluor® 633 Anti-human CD163 Antibody *GHI/61*

116300E0 100 tests
EUR 547

iFluor® 633 Anti-human CD163 Antibody *GHI/61*

116300E1 500 tests
EUR 2051

iFluor® 647 Anti-human CD163 Antibody *GHI/61*

116300F0 100 tests
EUR 547

iFluor® 647 Anti-human CD163 Antibody *GHI/61*

116300F1 500 tests
EUR 2051

iFluor® 660 Anti-human CD163 Antibody *GHI/61*

116300G0 100 tests
EUR 547

iFluor® 660 Anti-human CD163 Antibody *GHI/61*

116300G1 500 tests
EUR 2051

iFluor® 670 Anti-human CD163 Antibody *GHI/61*

116300H0 100 tests
EUR 547

iFluor® 670 Anti-human CD163 Antibody *GHI/61*

116300H1 500 tests
EUR 2051

iFluor® 680 Anti-human CD163 Antibody *GHI/61*

116300I0 100 tests
EUR 547

iFluor® 680 Anti-human CD163 Antibody *GHI/61*

116300I1 500 tests
EUR 2051

iFluor® 700 Anti-human CD163 Antibody *GHI/61*

116300J0 100 tests
EUR 547

iFluor® 700 Anti-human CD163 Antibody *GHI/61*

116300J1 500 tests
EUR 2051

iFluor® 710 Anti-human CD163 Antibody *GHI/61*

116300K0 100 tests
EUR 547

iFluor® 710 Anti-human CD163 Antibody *GHI/61*

116300K1 500 tests
EUR 2051

iFluor® 750 Anti-human CD163 Antibody *GHI/61*

116300L0 100 tests
EUR 547

iFluor® 750 Anti-human CD163 Antibody *GHI/61*

116300L1 500 tests
EUR 2051

iFluor® 790 Anti-human CD163 Antibody *GHI/61*

116300M0 100 tests
EUR 547

iFluor® 790 Anti-human CD163 Antibody *GHI/61*

116300M1 500 tests
EUR 2051

iFluor® 800 Anti-human CD163 Antibody *GHI/61*

116300N0 100 tests
EUR 547

iFluor® 800 Anti-human CD163 Antibody *GHI/61*

116300N1 500 tests
EUR 2051

iFluor® 810 Anti-human CD163 Antibody *GHI/61*

116300O0 100 tests
EUR 547

iFluor® 810 Anti-human CD163 Antibody *GHI/61*

116300O1 500 tests
EUR 2051

iFluor® 820 Anti-human CD163 Antibody *GHI/61*

116300P0 100 tests
EUR 547

iFluor® 820 Anti-human CD163 Antibody *GHI/61*

116300P1 500 tests
EUR 2051

iFluor® 840 Anti-human CD163 Antibody *GHI/61*

116300Q0 100 tests
EUR 547

iFluor® 840 Anti-human CD163 Antibody *GHI/61*

116300Q1 500 tests
EUR 2051

iFluor® 860 Anti-human CD163 Antibody *GHI/61*

116300R0 100 tests
EUR 547

iFluor® 860 Anti-human CD163 Antibody *GHI/61*

116300R1 500 tests
EUR 2051

iFluor® A7 Anti-human CD163 Antibody *GHI/61*

116300S0 100 tests
EUR 547

iFluor® A7 Anti-human CD163 Antibody *GHI/61*

116300S1 500 tests
EUR 2051

mFluor™ UV375 Anti-human CD163 Antibody *GHI/61*

116300X0 100 tests
EUR 547